Back to search

Article

PPARα-ERRα crosstalk mitigates metabolic dysfunction-associated steatotic liver disease progression

2024-10-16

Abstract excerpt

<h4>Background and aims</h4> Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most common liver disease worldwide. This study investigates how targeting two key nuclear receptors involved in hepatic energy metabolism, peroxisome proliferator-activated receptor alpha (PPARα) and estrogen-related receptor alpha (ERRα), impacts MASLD. <h4>Methods</h4> The PPARα agonist pemafibrate and/or...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
859d9b7b-8cc3-59d3-98c6-807669e996ee
DOI
10.1101/2024.10.14.618024
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
PPARα-ERRα crosstalk mitigates metabolic dysfunction-associated steatotic liver disease progressionDOI 10.1101/2024.10.14.618024
Unlocking therapeutic potential: exploring cross-talk among emerging nuclear receptors to combat metabolic dysfunction in steatotic liver diseaseSemantic proximity
Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug targetSemantic proximity
Multiomics analyses decipher intricate changes in the cellular and metabolic landscape of steatotic livers upon dietary restriction and sleeve gastrectomySemantic proximity
Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD)Semantic proximity
Hepatocyte ERα orchestrates sex-specific liver adaptation to fasting and feeding statesSemantic proximity
Sex- and hepatocyte PPARγ-dependent effects of an obesogenic dietary approach to induce MASH with fibrosis in miceSemantic proximity
Modulation of metabolic, inflammatory, fibrotic and cell death pathways by Resmetirom in metabolic dysfunction-associated steatohepatitis (MASH): A transcriptomic profiling studySemantic proximity
<i>Patolakaturohiniyadi Kashayam</i> , exerts anti-steatotic and anti-obesogenic effects via coordinated regulation of lipid metabolism, inflammation, and incretin signallingSemantic proximity
The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH modelSemantic proximity
Hepatocyte PPARγ contributes to the progression of non-alcoholic steatohepatitis in male and female obese miceSemantic proximity
A new dietary rat model fully recapitulates metabolic dysfunction-associated steatotic liver disease pathophysiology and mimics human disease with advanced liver fibrosis and portal hypertensionSemantic proximity
Hepatocyte-specific deletion of <i>Pparα</i> promotes NASH in the context of obesitySemantic proximity
Select a neighboring publication to make it the new centre.