Article

A Unified Mechanistic Framework for Metabolism-Based Therapeutics in MASH: A Comprehensive Review of SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Statins

2025-08-19

Abstract excerpt

Metabolic dysfunction-associated steatohepatitis (MASH) represents a multifaceted and progressive hepatic disorder that poses considerable therapeutic challenges in contemporary clinical practice. The therapeutic landscape has undergone substantial transformation with the identification of three pharmacologically distinct classes of metabolism-targeting agents, sodium-glucose cotransporter-2 (SGLT2) inhibitors, gl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb5e959c-3710-525a-adff-d9f36cfb3b9c
DOI: 10.20944/preprints202508.0991.v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Unified Mechanistic Framework for Metabolism-Based Therapeutics in MASH: A Comprehensive Review of SGLT2 Inhibitors, GLP-1 Receptor Agonists, and StatinsDOI 10.20944/preprints202508.0991.v3Read

Phenotypes of Metabolic Dysfunction-Associated Steatotic Liver Disease-Associated Hepatocellular Carcinoma.Semantic proximity Read

Metabolic Rewiring in MASLD: From Disease Mechanisms to Precision MedicineSemantic proximity Read

Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated steatotic liver disease by suppressing SIRT1Semantic proximity Read

Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPARα and PCK1 action in hepatocytesSemantic proximity Read

Combined Semaglutide and Exercise Ameliorate HFpEF-Associated MASH: Multi-Omics InsightsSemantic proximity Read

Regulation of Hepatic Stellate Cell Phenotypes in Metabolic Dysfunction-Associated Steatohepatitis.Semantic proximity Read

Multiomics analyses decipher intricate changes in the cellular and metabolic landscape of steatotic livers upon dietary restriction and sleeve gastrectomySemantic proximity Read

GTX-11 improves portal hypertension, liver fibrosis, and sinusoidal cells phenotype in experimental MASHSemantic proximity Read

Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)Semantic proximity Read

Hepatic HIF2α modulates extra-hepatic disease-associated phenotypes during metabolic dysfunction-associated steatotic liver diseaseSemantic proximity Read

Phenotype-Directed Precision Therapeutics: A Framework for Multi-Agonist Therapy in Obesity, MASH and Cardio-Renal-Metabolic DisordersSemantic proximity Read