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Potential role of the mTOR-C1-PGC1α-PPARα axis under type-II diabetes and hypertension in the human heart

2023-02-13

Abstract excerpt

<h4>Background: </h4> Type-2 diabetes (T2DM) and arterial hypertension (HTN) are major risk factors for heart failure. Importantly, these pathologies could induce synergetic alterations in the heart, and the discovery of key molecular signaling may suggest new targets for therapy. <h4>Methods and Results: </h4> Intraoperative cardiac biopsies were obtained from patients with or without HTN and/or T2DM. Control (n...

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Literature Corpus work
2cdfb505-a3a3-5ca0-98b0-202db6acc139
DOI
10.21203/rs.3.rs-2568258/v1
Open publication

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Potential role of the mTOR-C1-PGC1α-PPARα axis under type-II diabetes and hypertension in the human heartDOI 10.21203/rs.3.rs-2568258/v1
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