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Alzheimer's disease alters oligodendrocytic glycolytic and ketolytic gene expression

2 Mar 2021

Abstract excerpt

INTRODUCTION: Sporadic Alzheimer's disease (AD) is strongly correlated with impaired brain glucose metabolism, which may affect AD onset and progression. Ketolysis has been suggested as an alternative pathway to fuel the brain. METHODS: RNA-seq profiles of post mortem AD brains were used to determine whether dysfunctional AD brain metabolism can be determined by impairments in glycolytic and ketolytic gene...

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PMID: 33650792
DOI: 10.1002/alz.12310

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