Article

The ALS/FTD-linked protein CHCHD10 associates with the TDP-43 C-terminal domain through a CHCH–helix interface

2026-08-06

Abstract excerpt

<h4>ABSTRACT</h4> Aggregation and cytoplasmic mislocalization of TDP-43 are defining features of several neurodegenerative disorders including Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD). Yet the molecular interactions that regulate its transition from reversible assemblies to aggregation-prone states remain poorly understood. CHCHD10 is a mitochondrial protein genetically and pathologic...

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Literature Corpus work: f5c5b901-17a9-550f-bfa2-717129b0ffbd
DOI: 10.64898/2026.08.01.742190

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