Article

Aliphatic residues contribute significantly to the phase separation of TDP-43 C-terminal domain

2022-11-10

Abstract excerpt

TAR DNA binding protein 43 (TDP-43) is involved in key processes in RNA metabolism such as splicing, stability and transcription. TDP-43 dysfunction is frequently implicated in many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD). The prion-like, disordered C-terminal domain (CTD) of TDP-43 is aggregation-prone and harbors the majority (~90%) of all ALS-...

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Literature Corpus work: 40f74a1b-5f12-58cc-9edc-7b37424090bc
DOI: 10.1101/2022.11.10.516004

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