Article

TDP-43 self-assembly is regulated by its disordered NLS-region

2026-06-09

Abstract excerpt

Cytosolic inclusions of the RNA-binding protein TDP-43 are a pathological hallmark of several neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia. Cellular or animal model systems often use TDP-43 mutated in its nuclear localization signal (NLS) to study its cytosolic mislocalization and aggregation. Here we show that the disordered NLS-region, in particular the basic amin...

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Literature Corpus work: 1092ea06-af03-5ae9-a9a5-ea988ae5baff
DOI: 10.64898/2026.06.06.730435

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