Article
In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions.
Human molecular genetics - 1 Jan 2018
Burstein S R, Valsecchi F, Kawamata H, Bourens M, Zeng R, Zuberi A, Milner T A, Cloonan S M, Lutz C, Barrientos A, Manfredi G
Abstract excerpt
Mutations in coiled-coil-helix-coiled-coil-helix-domain containing 10 (CHCHD10), a mitochondrial twin CX9C protein whose function is still unknown, cause myopathy, motor neuron disease, frontotemporal dementia, and Parkinson's disease. Here, we investigate CHCHD10 topology and its protein interactome, as well as the effects of CHCHD10 depletion or expression of disease-associated mutations in wild-type cells. We...
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