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Article

Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10

4 Jul 2022

Abstract excerpt

Abstract Mutations in CHCHD10, a gene coding for a mitochondrial intermembrane space protein, are associated with Frontotemporal dementia (FTD)-Amyotrophic lateral sclerosis (ALS) spectrum disorders, which are pathologically characterized by cytoplasmic inclusions containing TDP-43. FTD/ALS-linked CHCHD10 mutations and TDP-43 inclusions similarly induce mitochondrial defects in respiration, fusion/fission, mtDNA...

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PMID: 35787294
DOI: 10.1186/s40478-022-01386-9

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