Article

Expanding the Huntington’s disease research toolbox; validated subdomain protein constructs for biochemical and structural investigation of huntingtin

2022-11-22

Abstract excerpt

Huntington’s disease is characterised by CAG expansion in the huntingtin gene above a critical threshold of ~ 35 repeats, resulting in polyglutamine expansion of the huntingtin protein (HTT). The biological role of wildtype HTT and the associated mechanisms of disease pathology caused by expanded HTT remain incompletely understood, in part, due to challenges characterising interactions between HTT and putative bi...

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Literature Corpus work: fb450444-3ff2-5fa4-9d9e-d5fee82ecaa1
DOI: 10.1101/2022.11.21.516512

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