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Article

Insight into the Folding and Dimerization Mechanisms of the N-Terminal Domain from Human TDP-43.

International journal of molecular sciences - 29 Aug 2020

Vivoli-Vega Mirella, Guri Prandvera, Chiti Fabrizio, Bemporad Francesco

Abstract excerpt

TAR DNA-binding protein 43 (TDP-43) is a 414-residue long nuclear protein whose deposition into intraneuronal insoluble inclusions has been associated with the onset of amyotrophic lateral sclerosis (ALS) and other diseases. This protein is physiologically a homodimer, and dimerization occurs through the N-terminal domain (NTD), with a mechanism on which a full consensus has not yet been reached. Furthermore, it...

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Identifiers

PMID: 32872449
DOI: 10.3390/ijms21176259
PMCID: PMC7504384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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