Article

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

2024-01-23

Abstract excerpt

<h4>SUMMARY</h4> Cytosolic aggregation of the nuclear protein TDP-43 is associated with many neurodegenerative diseases, but the triggers for TDP-43 aggregation are still debated. Here, we demonstrate that TDP-43 aggregation requires a double event. One is up-concentration in stress granules beyond a threshold, and the other is oxidative stress. These two events collectively induce intra-condensate demixing, givi...

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Literature Corpus work: bb33f1e9-4c31-5ed3-bc24-25e72dcc5a27
DOI: 10.1101/2024.01.23.576837

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