Article

Structural details of helix-mediated TDP-43 C-terminal domain multimerization

2024-07-06

Abstract excerpt

The primarily disordered C-terminal domain (CTD) of TAR DNA binding protein-43 (TDP-43), a key nuclear protein in RNA metabolism, forms neuronal inclusions in several neurodegenerative diseases. A conserved region (CR, spanning residues 319-341) in CTD forms transient helix-helix contacts important for its higher-order oligomerization and function that are disrupted by ALS-associated mutations. However, the struct...

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Literature Corpus work: 31dc0c66-0698-5315-b77a-8ca40c7cf686
DOI: 10.1101/2024.07.05.602258

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