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Article

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

2021-04-02

Abstract excerpt

Huntington’s disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene, producing an aberrantly functioning form of HTT. Both wildtype and disease-state HTT form a hetero-dimer with HAP40 of unknown functional relevance. We demonstrate in vivo that HTT and HAP40 cellular abundance are coupled. Integrating data from a 2.6 Å cryo-electron microscopy structure, cross-linking mass sp...

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Identifiers and source

Literature Corpus work
fd95f87b-9c6c-535b-9924-2d6ebc3c5917
DOI
10.1101/2021.04.02.438217
Open publication

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HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1DOI 10.1101/2021.04.02.438217
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