Article

Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation

2021-04-30

Abstract excerpt

Post-translational modifications (PTMs) have emerged as key modulators of protein phase separation and have been linked to protein aggregation in neurodegenerative disorders. The major aggregating protein in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the RNA-binding protein TDP-43, is hyperphosphorylated in disease on several C-terminal serine residues, which is generally believed to pr...

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Literature Corpus work: 4d0961b1-38aa-50d0-881c-f119998a523c
DOI: 10.1101/2021.04.30.442163

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