Article

Misfolded amyloid β-42 induced impairment of the endosomal-lysosomal pathway revealed by real-time optical monitoring

2019-04-05

Abstract excerpt

<h4>ABSTRACT</h4> Misfolding and aggregation of proteins is strongly linked to several neurodegenerative diseases but how such species bring about their cytotoxic actions remains poorly understood. Here we used specifically-designed optical reporter probes and live fluorescence imaging in primary hippocampal neurons to characterise the mechanism by which prefibrillar, oligomeric forms of the Alzheimer’s-associate...

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Literature Corpus work: f537ed7f-d6b5-5ae6-b07f-2847ab8879b5
DOI: 10.1101/598540

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