Article

Endo-lysosomal Aβ concentration and pH enable formation of Aβ oligomers that potently induce Tau missorting

2020-06-28

Abstract excerpt

Amyloid-β peptide (Aβ) forms metastable oligomers >50 kD, termed AβOs or protofibrils, that are more effective than Aβ amyloid fibrils at triggering Alzheimer’s disease-related processes such as synaptic dysfunction and Tau pathology, including Tau mislocalization. In neurons, Aβ accumulates in endo-lysosomal vesicles at low pH. Here, we show that the rate of AβO assembly is accelerated 8,000-fold upon pH reductio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eca390f7-cc62-51a1-b243-69c1f7d2f917
DOI: 10.1101/2020.06.28.175885

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Endo-lysosomal Aβ concentration and pH enable formation of Aβ oligomers that potently induce Tau missortingDOI 10.1101/2020.06.28.175885Read

Misfolded amyloid β-42 induced impairment of the endosomal-lysosomal pathway revealed by real-time optical monitoringSemantic proximity Read

EndophilinA-dependent coupling between activity-dependent calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutationSemantic proximity Read

Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer’s diseaseSemantic proximity Read

Lysosomal enzyme tripeptidyl peptidase 1 plays a role in degradation of beta amyloid fibrilsSemantic proximity Read

Endophilin-A/SH3GL2 calcium switch for synaptic autophagy induction is impaired by a Parkinson's risk variant.Semantic proximity Read

Lysosomal proteolysis of amyloid beta is impeded by fibrils grown in both acidic and neutral pH environmentsSemantic proximity Read

Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytesSemantic proximity Read

Endocytosis is regulated through the pH-dependent phosphorylation of Rab GTPases by Parkinson’s kinase LRRK2Semantic proximity Read

β2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7.Semantic proximity Read

Lysosomal Protease-Mediated APP Degradation is pH-Dependent, Mutation-Sensitive, and Facilitates Tau ProteolysisSemantic proximity Read

Endocytosis is regulated through the pH-dependent phosphorylation of Rab GTPases by Parkinson’s kinase LRRK2Semantic proximity Read

EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation.Semantic proximity Read