Article

Apolipoprotein-E transforms intracellular Amyloid-β oligomers to a more toxic state

2023-09-03

Abstract excerpt

It is poorly understood why ApoE variants are major genetic risk factors in Alzheimer’s disease (AD), which is associated with the aggregation of amyloid beta (Aβ). Here we directly image specific changes in small Aβ oligomers in rat brain cells that correlate with the cellular ApoE content. An inhibitor of Aβ-ApoE interaction suppresses this change and concomitantly reduces Aβ toxicity in a dose-dependent manner....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: baba771d-d535-5b2c-9183-d2deaa6b5dc5
DOI: 10.1101/2023.09.03.556061

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein-E transforms intracellular Amyloid-β oligomers to a more toxic stateDOI 10.1101/2023.09.03.556061Read

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's diseaseSemantic proximity Read

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer’s diseaseSemantic proximity Read

ApoE lipidation, not isoform, is the key modulator of Aβ interaction, uptake, and cytotoxicitySemantic proximity Read

The Toxicity and Polymorphism of β-Amyloid OligomersSemantic proximity Read

Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer’s disease mouse modelSemantic proximity Read

In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human NeuronsSemantic proximity Read

TNF⍺-driven Aβ aggregation, synaptic dysfunction and hypermetabolism in human iPSC-derived cortical neuronsSemantic proximity Read

APOE-amyloid interaction: Therapeutic targets.Semantic proximity Read

Domino-like Effect of C112R Mutation on ApoE4 Aggregation and Its Reduction by Alzheimer’s Disease Drug CandidateSemantic proximity Read

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.Semantic proximity Read

Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer’s disease (AD) riskSemantic proximity Read

Silencing of <i>ApoE</i> with Divalent siRNAs Drives Activation of Immune Clearance Pathways and Improves Amyloid Pathology in Mouse Models of Alzheimer’s DiseaseSemantic proximity Read