Article

Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytes

2025-06-01

Abstract excerpt

Astrocytes are essential for brain homeostasis and are involved in amyloid-β (Aβ) clearance, but whether they can produce and release Aβ aggregates remains unclear. Using human iPSC-derived astrocytes, we show that astrocytes cell autonomously generate small, diffusible Aβ aggregates under baseline conditions. By combining ultrasensitive single-molecule imaging (DNA-PAINT) and immunoassays, we detect intracellular...

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Literature Corpus work: 7e75d74b-6b0c-58be-8c15-9ecd29108f88
DOI: 10.1101/2025.05.27.656416

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