Article

Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer’s disease

2022-08-26

Abstract excerpt

Impairments in neural lysosomal- and autophagic-mediated degradation of cellular debris contribute to neuritic dystrophy and synaptic loss. While these are well-characterized features of neurodegenerative disorders such as Alzheimer’s disease (AD), the upstream cellular processes driving deficits in pathogenic protein mishandling are less understood. Using a series of fluorescent biosensors and optical imaging in...

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Literature Corpus work: de9c9430-9cb1-59f3-a0e7-1afaab9224cf
DOI: 10.1101/2022.08.24.505157

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