Back to search

Article

Aβ-aggregation-generated blue autofluorescence illuminates senile plaques, complex blood and vascular pathologies in the Alzheimer’s disease

2023-07-07

Abstract excerpt

Senile plaque blue autofluorescence in the Alzheimer’s disease (AD) was discovered around 40 years ago, however, its impact on AD pathology is not fully examined. We analyzed senile plaques with immunohistochemistry and fluorescence imaging on AD brain pathological sections and also the Aβ aggregation process in vitro in test tubes. In DAPI or Hoechst staining experiments, the data showed that the nuclear blue fl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a3ab48e5-a84a-59e3-a3aa-e726ecb2b4d3
DOI
10.1101/2023.07.06.548042
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Aβ-aggregation-generated blue autofluorescence illuminates senile plaques, complex blood and vascular pathologies in the Alzheimer’s diseaseDOI 10.1101/2023.07.06.548042
Senile plaques in Alzheimer’s disease arise from Aβ and Cathepsin D-enriched amyloidogenic mixtures out of intravascular hemolysis and Charcot-Bouchard aneurysm-related vascular degenerationSemantic proximity
Misfolded amyloid β-42 induced impairment of the endosomal-lysosomal pathway revealed by real-time optical monitoringSemantic proximity
Biochemistry of Alzheimer's disease amyloid plaques.Semantic proximity
The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease.Semantic proximity
Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization and hemorrhage is a major defect in Alzheimer’s diseaseSemantic proximity
β-Amyloid Protein Induces Mitophagy-Dependent Ferroptosis Through the CD36/PINK/PARKIN Pathway Leading to Blood-Brain Barrier Destruction in Alzheimer's DiseaseSemantic proximity
Sensitive Detection of Proteopathic Seeding Activity with FRET Flow CytometrySemantic proximity
Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation.Semantic proximity
Early Detection of Tau PathologySemantic proximity
Intracellular A? and its Pathological Role in Alzheimer's Disease: Lessons from Cellular to Animal ModelsSemantic proximity
Critical role of intraneuronal Aβ in Alzheimer's disease: Technical challenges in studying intracellular AβSemantic proximity
A Modification of the Bielschowsky Silver Stain for Alzheimer Neuritic Plaques: Suppression of Artifactual Staining by Pretreatment with Oxidizing AgentsSemantic proximity
Select a neighboring publication to make it the new centre.