Article

p21-activated kinase regulates Rab3a vesicles to repair plasma membrane damage caused by Amyloid-β oligomers

2025-02-15

Abstract excerpt

The interaction of amyloid-β (Aβ) peptides with the plasma membrane (PM) is a potential trigger that initiates the formation of higher-order aggregates, membrane alterations/damage, and progressive neurotoxicity in Alzheimer’s disease (AD). In a previous study, we showed that oligomers of Aβ 1-42 (oAβ 1-42 ) induced PM damage, resulting in PM repair cascade via lysosomal exocytosis coupled with endocytosis, and...

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Literature Corpus work: d8f1055e-3328-5d6e-9f41-021273d38d23
DOI: 10.1101/2025.02.11.637764

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