Article

Deconvolution-based cell-type specific DNA methylation-wide and transcriptome-wide association studies identify risk CpG sites and genes associated with colorectal cancer risk

2026-06-12

Abstract excerpt

<h4>ABSTRACT</h4> Bulk tissue-based DNA methylation-wide (MWAS) and transcriptome-wide association studies (TWAS) have identified CpG sites and genes associated with colorectal cancer (CRC) risk, but do not account for cellular heterogeneity. To address this, we developed a deconvolution-informed framework to infer cell-type specific DNA methylation and gene expression profiles from bulk normal colon tissues usin...

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Literature Corpus work: 74240fee-5d06-5037-8a40-7f70af5e0d05
DOI: 10.64898/2026.06.11.26355460

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