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Article

Dysregulated immune microenvironment in metastatic colorectal cancer.

Medical oncology (Northwood, London, England) - 24 Feb 2026

An Shuaixing, Yu Zhaojin, Li Jianping, Wei Minjie

Abstract excerpt

Emerging evidence highlights that metastatic colorectal cancer (mCRC) can occur early in tumor progression, with its unique genomic characteristics contributing to an altered immune landscape. This study aims to elucidate the molecular and immune mechanisms that drive mCRC progression and therapeutic resistance. By leveraging multi-omics data, we examined immune infiltration, immune subtypes, tumor mutational...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41733844
DOI: 10.1007/s12032-025-03112-6

Genes

MUC16
TAP1
CD274
CD74
CTLA4
CXCL9
EDNRB
GZMA
HMGB1
IFNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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