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Article

DNA hypomethylation patterns and their impact on the tumor microenvironment in colorectal cancer.

Cellular oncology (Dordrecht, Netherlands) - 1 Aug 2024

Huang He, Li Qian, Tu Xusheng, Yu Dongyue, Zhou Yundong, Ma Lifei, Wei Kongyuan, Gao Yuzhen, Zhao Guodong, Han Ruiqin, Ye Fangdie, Ke Chunlian

Abstract excerpt

BACKGROUND: Recent research underscores the pivotal role of immune checkpoints as biomarkers in colorectal cancer (CRC) therapy, highlighting the dynamics of resistance and response to immune checkpoint inhibitors. The impact of epigenetic alterations in CRC, particularly in relation to immune therapy resistance, is not fully understood. METHODS: We integrated a comprehensive dataset encompassing TCGA-COAD,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38520647
DOI: 10.1007/s13402-024-00933-x
PMCID: PMC12974014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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