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Methylation-Guided Stratification of Colorectal Cancer Reveals Immune Subtypes with Distinct Clinical Outcomes

2026-02-04

Abstract excerpt

<h4>Background</h4> Aberrant DNA methylation is a hallmark of colorectal cancer (CRC). Yet, how DNA methylation is linked to transcriptional states, immune programs, and tissue resident microbiome within the same tumors has not been systematically analyzed. <h4>Methods</h4> We profiled genome-wide DNA methylation (Illumina MethylationEPIC) in 182 colon tumors and 76 adjacent normals from AC-ICAM, and integrated...

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Literature Corpus work
85bab5da-2aa0-5758-9267-ed52dbf8fecf
DOI
10.64898/2026.02.03.703457
Open publication

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Methylation-Guided Stratification of Colorectal Cancer Reveals Immune Subtypes with Distinct Clinical OutcomesDOI 10.64898/2026.02.03.703457
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