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Article

Stage-differentiated modelling of methylation patterns uncovers salient biomarkers and prognostic signatures in colorectal cancer progression

2020-09-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Aberrant methylation of DNA acts epigenetically to skew the gene transcription rate up or down. In this study, we have developed a comprehensive computational framework for the stage-specific analysis of methylation patterns in colorectal cancer. <h4>Methods</h4> Combining public-domain methylation and clinical data from TCGA, the methylation β - matrix was converted into M-va...

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Literature Corpus work
afd3d728-99f7-511c-8ba0-f7bd09de6b38
DOI
10.1101/2020.09.28.20203539
Open publication

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Stage-differentiated modelling of methylation patterns uncovers salient biomarkers and prognostic signatures in colorectal cancer progressionDOI 10.1101/2020.09.28.20203539
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