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Stage-differentiated modelling of DNA methylation landscapes uncovers salient biomarkers and prognostic signatures in colorectal cancer progression

2021-02-26

Abstract excerpt

<h4>Background: </h4> Aberrant DNA methylation acts epigenetically to skew the gene transcription rate up or down, with causative roles in the etiology of cancers. However research on the role of DNA methylation in driving the progression of cancers is limited. In this study, we have developed a comprehensive computational framework for the stage-differentiated modelling of DNA methylation landscapes in colorectal...

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Literature Corpus work
5de4398b-9c97-5ec1-8a9c-275080b5e63c
DOI
10.21203/rs.3.rs-244816/v1
Open publication

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Stage-differentiated modelling of DNA methylation landscapes uncovers salient biomarkers and prognostic signatures in colorectal cancer progressionDOI 10.21203/rs.3.rs-244816/v1
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