Article

Naturally occurring mutations in the HBV core N-terminal domain reduce viral replication and HBeAg levels

2026-08-19

Abstract excerpt

The N-terminal domain (NTD) of hepatitis B virus (HBV) core region (C region) plays crucial role in its life cycle, while the functional implications of related mutations remain unclear. This study aimed to characterize the emergence of mutations in the HBV C region and investigate the impact of high-frequency C region mutations on HBV life cycle. Three hundred twenty-six HBV samples were collected from 32 blood e...

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Literature Corpus work: f50b655f-889f-5465-9e6b-e6358f5c2a84
DOI: 10.1186/s10020-026-01608-z

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