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Article

Overview of hepatitis B viral replication and genetic variability.

Journal of hepatology - 1 Apr 2016

Tong Shuping, Revill Peter

Abstract excerpt

Chronic infection with hepatitis B virus (HBV) greatly increases the risk for liver cirrhosis and hepatocellular carcinoma (HCC). HBV isolates worldwide can be divided into ten genotypes. Moreover, the immune clearance phase selects for mutations in different parts of the viral genome. The outcome of HBV infection is shaped by the complex interplay of the mode of transmission, host genetic factors, viral genotype...

Topics

DNA, Viral
Genome, Viral
Hepatitis B
Hepatitis B virus
Humans
Mutation
Promoter Regions, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27084035
DOI: 10.1016/j.jhep.2016.01.027
PMCID: PMC4834849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27084035-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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