Hepatitis B virus core variants modify natural course of viral infection and hepatocellular carcinoma progression.

doi:10.1053/j.gastro.2009.07.063

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Article

Hepatitis B virus core variants modify natural course of viral infection and hepatocellular carcinoma progression.

Gastroenterology - 1 Nov 2009

Sung Feng-Yu, Jung Chun-Ming, Wu Chih-Feng, Lin Chih-Lin, Liu Chun-Jen, Liaw Yun-Fan, Tsai Keh-Sung, Yu Ming-Whei

Abstract excerpt

BACKGROUND & AIMS: We assessed the influence of genetic variants in the hepatitis B virus (HBV) core, which is a principal immunologic target, on the progression to hepatocellular carcinoma (HCC) in a cohort of 4841 male HBV carriers followed up for 16 years. METHODS: First, baseline sera from 116 HCC cases and 154 controls nested within the cohort were used for sequencing of the HBV core gene to screen for...

Topics

Adult
Carcinoma, Hepatocellular
Case-Control Studies
Codon, Terminator
Cohort Studies
Genetic Variation
Hepatitis B
Hepatitis B virus
Humans
Liver Neoplasms
Male
Middle Aged
Viral Core Proteins
Viral Load

Source

Open in PubMed

Identifiers

PMID: 19664630
DOI: 10.1053/j.gastro.2009.07.063

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