The characteristic changes in hepatitis B virus x region for hepatocellular carcinoma: a comprehensive analysis based on global data.

doi:10.1371/journal.pone.0125555

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The characteristic changes in hepatitis B virus x region for hepatocellular carcinoma: a comprehensive analysis based on global data.

PloS one - 1 Jan 2015

Li Wenwen, Goto Kaku, Matsubara Yasuo, Ito Sayaka, Muroyama Ryosuke, Li Qiang, Kato Naoya

Abstract excerpt

OBJECTIVES: Mutations in hepatitis B virus (HBV) X region (HBx) play important roles in hepatocarcinogenesis while the results remain controversial. We sought to clarify potential hepatocellular carcinoma (HCC)-characteristic mutations in HBx from HBV genotype C-infected patients and the distribu...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma, Hepatocellular
Cell Transformation, Viral
Child
Child, Preschool
Computational Biology
Databases, Nucleic Acid
Female
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Global Health

Hepatitis B

Hepatitis B virus

Humans

Liver Neoplasms

Male

Source

Open in PubMed Open full text

Identifiers

PMID: 25942596
DOI: 10.1371/journal.pone.0125555
PMCID: PMC4420286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-25942596-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The characteristic changes in hepatitis B virus x region for hepatocellular carcinoma: a comprehensive analysis based on global data.PMID 25942596Read ↗

Comparison of hepatitis B X gene mutation between patients with hepatocellular carcinoma and patients with chronic hepatitis B.Semantic proximity Read ↗

X region mutations of hepatitis B virus related to clinical severity.Semantic proximity Read ↗

Comparison of the Characteristics of Hepatitis B Virus Whole Genomes Derived From Patients With Hepatocellular Carcinoma and Chronic Hepatitis B InfectionSemantic proximity Read ↗

Evolutionary and functional landscape of HBx mutations in genotype D1 HBV: comparative insights from acute infection, chronic hepatitis, and HCCSemantic proximity Read ↗

The oncogenic role of hepatitis B virus X gene in hepatocarcinogenesis: recent updatesSemantic proximity Read ↗

Comparison Study on Characteristics of Hepatitis B Virus Whole Genomes for Hepatocellular Carcinoma and Chronic Hepatitis B PatientsSemantic proximity Read ↗

Hepatitis B virus-induced hepatocellular carcinoma.Semantic proximity Read ↗

The Role of HBx Mutations in Chronic Hepatitis B with Acute Exacerbation.Semantic proximity Read ↗

Hepatitis B virus genotype distribution and mutation patterns: Insights and clinical implications for hepatitis B virus positive patientsSemantic proximity Read ↗

HBV genotypes: relevance to natural history, pathogenesis and treatment of chronic hepatitis B.Semantic proximity Read ↗

X gene mutations of Hepatitis B virus and impact on chronic hepatitis B infection in CHB three-generations in the familySemantic proximity Read ↗

Comprehensive Analysis of Hepatitis B Virus Promoter Region MutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.