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Article

The characteristic changes in hepatitis B virus x region for hepatocellular carcinoma: a comprehensive analysis based on global data.

PloS one - 1 Jan 2015

Li Wenwen, Goto Kaku, Matsubara Yasuo, Ito Sayaka, Muroyama Ryosuke, Li Qiang, Kato Naoya

Abstract excerpt

OBJECTIVES: Mutations in hepatitis B virus (HBV) X region (HBx) play important roles in hepatocarcinogenesis while the results remain controversial. We sought to clarify potential hepatocellular carcinoma (HCC)-characteristic mutations in HBx from HBV genotype C-infected patients and the distribution of those mutations in different disease phases and genotypes. METHODS: HBx sequences downloaded from an online...

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Identifiers

PMID: 25942596
DOI: 10.1371/journal.pone.0125555
PMCID: PMC4420286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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