Unraveling the Role of Mutations Outside the Basal Promoter and Precore Regions in the HBeAg-Negative Stage of Chronic Hepatitis B.

doi:10.1002/jmv.70398

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Article

Unraveling the Role of Mutations Outside the Basal Promoter and Precore Regions in the HBeAg-Negative Stage of Chronic Hepatitis B.

Journal of medical virology - 1 May 2025

Elizalde María Mercedes, Monzani María Cecilia, Favale Nicolás Octavio, Bouzas Belén, Mammana Lilia, Campos Rodolfo, Flichman Diego

Abstract excerpt

Hepatitis B e antigen (HBeAg) seroconversion is a crucial event in the natural history of chronic hepatitis B virus (HBV) infection, marked by a significant decrease in viral load and the emergence of mutations that suppress HBeAg expression. However, these mutations alone do not fully account for the reduction in viral load. This study investigated the biological features and pathogenic roles of mutations...

Read the complete abstract on PubMed

Topics

Humans
Hepatitis B, Chronic
Hepatitis B e Antigens
Hepatitis B virus
Promoter Regions, Genetic
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genotype

DNA, Viral

Genome, Viral

Viral Load

Male

Female

Adult

Source

Open in PubMed

Identifiers

PMID: 40400367
DOI: 10.1002/jmv.70398

Provenance

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