Article

Evolutionary and functional landscape of HBx mutations in genotype D1 HBV: comparative insights from acute infection, chronic hepatitis, and HCC

2026-08-13

Abstract excerpt

HBV infection remains a major global health burden and a leading cause of hepatocellular carcinoma (HCC), with viral genetic variability contributing to the heterogeneity of clinical outcomes. Among HBV proteins, HBx functions as a multifunctional regulatory protein involved in viral replication, host transcriptional regulation, apoptosis, immune signaling, and oncogenic pathways. Although HBx biology has been ext...

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Literature Corpus work: 18aa6d03-ee3f-5401-b7c2-0028fd9c9107
DOI: 10.1186/s13027-026-00789-w

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