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Article

Impact of core protein naturally selected mutants associated with HBeAg-negative status in HBV biosynthesis.

Journal of medical virology - 1 Oct 2023

Elizalde María Mercedes, Giadans Cecilia Graciela, Campos Rodolfo Héctor, Flichman Diego Martín

Abstract excerpt

Hepatitis B e antigen (HBeAg) loss represents a late stage of chronic hepatitis B virus (HBV) infection associated with a drastic decrease in HBV-DNA, a lower risk of disease progression, and the occurrence of several mutations in the preCore/core region. However, the underlying mechanisms supporting the downregulation of viral replication have yet to be elucidated. In the present study, the analysis of the...

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Identifiers

PMID: 37881005
DOI: 10.1002/jmv.29195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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