Article

Identifying the causal allele in the CD40 autoimmune locus enables discovery of context-specific trans-effects in B cells

2026-08-04

Abstract excerpt

Thousands of genetic variants are associated with autoimmune diseases, but causal variants, their mechanisms, and the pathogenic context in which they act are elusive. Knowledge of pathogenic contexts may enable effective targeted therapies, instead of broad immunosuppressive approaches. First, to focus on the genetics of immune response, we used surface marker CITE-seq data from 1,055,857 peripheral blood mononuc...

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Literature Corpus work: f5034f38-0e8e-5b0c-8ade-d812f4a2d849
DOI: 10.64898/2026.07.29.741564

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