Article

Resolving mechanisms of immune-mediated disease in primary CD4 T cells

2020-01-17

Abstract excerpt

<h4>ABSTRACT</h4> Deriving mechanisms of immune-mediated disease from GWAS data remains a formidable challenge, with attempts to identify causal variants being frequently hampered by linkage disequilibrium. To determine whether causal variants could be identified via their functional effects, we adapted a massively-parallel reporter assay for use in primary CD4 T-cells, key effectors of many immune-mediated disea...

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Literature Corpus work: 5c791bf2-980a-5a1d-b51b-19c8e8ffee30
DOI: 10.1101/2020.01.16.908988

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