Article
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
Nature genetics - 1 Oct 2008
Raychaudhuri Soumya, Remmers Elaine F, Lee Annette T, Hackett Rachel, Guiducci Candace, Burtt Noël P, Gianniny Lauren, Korman Benjamin D, Padyukov Leonid, Kurreeman Fina A S, Chang Monica, Catanese Joseph J, Ding Bo, Wong Sandra, van der Helm-van Mil Annette H M, Neale Benjamin M, Coblyn Jonathan, Cui Jing, Tak Paul P, Wolbink Gert Jan, Crusius J Bart A, van der Horst-Bruinsma Irene E, Criswell Lindsey A, Amos Christopher I, Seldin Michael F, Kastner Daniel L, Ardlie Kristin G, Alfredsson Lars, Costenbader Karen H, Altshuler David, Huizinga Tom W J, Shadick Nancy A, Weinblatt Michael E, de Vries Niek, Worthington Jane, Seielstad Mark, Toes Rene E M, Karlson Elizabeth W, Begovich Ann B, Klareskog Lars, Gregersen Peter K, Daly Mark J, Plenge Robert M
Abstract excerpt
To identify rheumatoid arthritis risk loci in European populations, we conducted a meta-analysis of two published genome-wide association (GWA) studies totaling 3,393 cases and 12,462 controls. We genotyped 31 top-ranked SNPs not previously associated with rheumatoid arthritis in an independent replication of 3,929 autoantibody-positive rheumatoid arthritis cases and 5,807 matched controls from eight separate...
Topics
- Arthritis, Rheumatoid
- CD40 Antigens
- Case-Control Studies
- Chromosome Mapping
- Chromosomes, Human
- Genetic Linkage