Article
Resolving mechanisms of immune-mediated disease in primary CD4 T cells.
EMBO molecular medicine - 8 May 2020
Bourges Christophe, Groff Abigail F, Burren Oliver S, Gerhardinger Chiara, Mattioli Kaia, Hutchinson Anna, Hu Theodore, Anand Tanmay, Epping Madeline W, Wallace Chris, Smith Kenneth Gc, Rinn John L, Lee James C
Abstract excerpt
Deriving mechanisms of immune-mediated disease from GWAS data remains a formidable challenge, with attempts to identify causal variants being frequently hampered by strong linkage disequilibrium. To determine whether causal variants could be identified from their functional effects, we adapted a massively parallel reporter assay for use in primary CD4 T cells, the cell type whose regulatory DNA is most enriched...
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