Article

Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity

2022-10-21

Abstract excerpt

<h4>ABSTRACT</h4> Type 2 diabetes (T2D) is associated with compromised identity of insulin-producing pancreatic islet beta (β) cells, characterized by inappropriate production of other islet cell-enriched hormones. Here we examined how hormone misexpression was influenced by the MAFA and MAFB transcription factors, closely related proteins that maintain islet cell function. Mice specifically lacking MafA in β cel...

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Literature Corpus work: f467b43f-86b4-5b08-95d4-74bfa34ac0d5
DOI: 10.1101/2022.10.20.512880

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