Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MAFA and MAFB regulate exocytosis‐related genes in human β‐cells

3 Jan 2022

Abstract excerpt

Abstract Aims Reduced expression of exocytotic genes is associated with functional defects in insulin exocytosis contributing to impaired insulin secretion and type 2 diabetes (T2D) development. MAFA and MAFB transcription factors regulate β‐cell physiology, and their gene expression is reduced in T2D β cells. We investigate if loss of MAFA and MAFB in human β cells contributes to T2D progression by regulating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular transport and secretion
Share to Congenital heart defects research
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34978761
DOI: 10.1111/apha.13761

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MAFA and MAFB regulate exocytosis‐related genes in human β‐cellsPMID 34978761Read ↗

MAFB is essential for the maintenance of adult human α-cell identity and glucagon secretionSemantic proximity Read ↗

Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetesSemantic proximity Read ↗

Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identitySemantic proximity Read ↗

Multi-omics analysis of long-term cultured human isletsSemantic proximity Read ↗

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cellsSemantic proximity Read ↗

RFX6 Maintains Gene Expression and Function of Adult Human Islet α-CellsSemantic proximity Read ↗

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In VivoSemantic proximity Read ↗

Combinatorial transcription factor profiles predict mature and functional human islet α and β cellsSemantic proximity Read ↗

Combinatorial transcription factor profiles predict mature and functional human islet α and β cellsSemantic proximity Read ↗

MAFA Phosphorylation Controls Beta-Cell Identity and Sex-Specific Pancreatic Disease OutcomesSemantic proximity Read ↗

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell FunctionSemantic proximity Read ↗

Loss of the transcription factor MAFB limits β-cell derivation from human PSCsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.