Article

MAFB is essential for the maintenance of adult human α-cell identity and glucagon secretion

2026-08-14

Abstract excerpt

Dysregulated hormone secretion and erosion of endocrine cell identity are features of type 1 and type 2 diabetes, but the transcriptional programs maintaining adult human islet identity and function remain poorly defined. The large MAF transcription factor MAFB is expressed in human α- and β-cells, marks their most functionally mature subpopulations, and is downregulated in diabetes, but its role in adult human is...

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Literature Corpus work: 6be1a954-c6c0-5653-b75a-b81a9cf6f852
DOI: 10.64898/2026.08.08.743687

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