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Article

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells

11 Nov 2015

Abstract excerpt

Analysis of MafB(-/-) mice has suggested that the MAFB transcription factor was essential to islet α- and β-cell formation during development, although the postnatal physiological impact could not be studied here because these mutants died due to problems in neural development. Pancreas-wide mutant mice were generated to compare the postnatal significance of MafB (MafB(Δpanc)) and MafA/B (MafAB(Δpanc)) with...

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PMID: 26554594
DOI: 10.1152/ajpendo.00285.2015

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Related research

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The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cellsPMID 26554594Read ↗

MafB is required for islet beta cell maturation.Semantic proximity Read ↗

Loss of the transcription factor MAFB limits β-cell derivation from human PSCsSemantic proximity Read ↗

Examining How the MAFB Transcription Factor Affects Islet β-Cell Function PostnatallySemantic proximity Read ↗

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In VivoSemantic proximity Read ↗

Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identitySemantic proximity Read ↗

MAFB is essential for the maintenance of adult human α-cell identity and glucagon secretionSemantic proximity Read ↗

MAFA Phosphorylation Controls Beta-Cell Identity and Sex-Specific Pancreatic Disease OutcomesSemantic proximity Read ↗

Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse.Semantic proximity Read ↗

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell FunctionSemantic proximity Read ↗

MAFA and MAFB regulate exocytosis‐related genes in human β‐cellsSemantic proximity Read ↗

Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell.Semantic proximity Read ↗

Combinatorial transcription factor profiles predict mature and functional human islet α and β cellsSemantic proximity Read ↗

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