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Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally

13 Nov 2018

Abstract excerpt

The sustained expression of the MAFB transcription factor in human islet β-cells represents a distinct difference in mice. Moreover, mRNA expression of closely related and islet β-cell–enriched MAFA does not peak in humans until after 9 years of age. We show that the MAFA protein also is weakly produced within the juvenile human islet β-cell population and that MafB expression is postnatally restricted in mouse...

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PMID: 30425060
DOI: 10.2337/db18-0903

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