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Article

MafB is required for islet beta cell maturation.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2007

Artner Isabella, Blanchi Bruno, Raum Jeffrey C, Guo Min, Kaneko Tomomi, Cordes Sabine, Sieweke Michael, Stein Roland

Abstract excerpt

Pancreatic endocrine cell differentiation depends on transcription factors that also contribute in adult insulin and glucagon gene expression. Islet cell development was examined in mice lacking MafB, a transcription factor expressed in immature alpha (glucagon(+)) and beta (insulin(+)) cells and...

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Identifiers

PMID: 17360442
DOI: 10.1073/pnas.0700013104
PMCID: PMC1803762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17360442-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

MafB is required for islet beta cell maturation.PMID 17360442Read ↗

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cellsSemantic proximity Read ↗

Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identitySemantic proximity Read ↗

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In VivoSemantic proximity Read ↗

Crucial Role of PDX-1 in Pancreas Development, β-Cell Differentiation, and Induction of Surrogate β-CellsSemantic proximity Read ↗

Loss of the transcription factor MAFB limits β-cell derivation from human PSCsSemantic proximity Read ↗

FoxA2, Nkx2.2, and PDX-1 Regulate Islet β-Cell-Specific mafA Expression through Conserved Sequences Located between Base Pairs −8118 and −7750 Upstream from the Transcription Start SiteSemantic proximity Read ↗

Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.Semantic proximity Read ↗

Examining How the MAFB Transcription Factor Affects Islet β-Cell Function PostnatallySemantic proximity Read ↗

Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse.Semantic proximity Read ↗

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell IdentitySemantic proximity Read ↗

PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regenerationSemantic proximity Read ↗

PAX6 maintains β cell identity by repressing genes of alternative islet cell typesSemantic proximity Read ↗

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