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Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs

2020-10-14

Abstract excerpt

The loss of pancreatic β-cell identity emerges as an important feature of type 2 diabetes development, but the molecular mechanisms are still elusive. Here, we explore the cell-autonomous role of the cell cycle regulator and transcription factor E2F1 in the maintenance of β-cell identity and insulin secretion. We show that the β-cell-specific loss of E2f1 function in mice triggers glucose intolerance associated w...

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Literature Corpus work: 7b254c1b-6740-50ac-aea8-434881e82f6e
DOI: 10.1101/2020.10.14.339929

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Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programsDOI 10.1101/2020.10.14.339929Read

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Pancreatic β-cell specific loss of <i>E2f1</i> impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs

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