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Article

Loss of the transcription factor MAFB limits β-cell derivation from human PSCs

2 Jun 2020

Abstract excerpt

Next generation sequencing studies have highlighted discrepancies in β-cells which exist between mice and men. Numerous reports have identified MAF BZIP Transcription Factor B (MAFB) to be present in human β-cells postnatally, while its expression is restricted to embryonic and neo-natal β-cells in mice. Using CRISPR/Cas9-mediated gene editing, coupled with endocrine cell differentiation strategies, we dissect...

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PMID: 32488111
DOI: 10.1038/s41467-020-16550-9

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