Article

MAFA Phosphorylation Controls Beta-Cell Identity and Sex-Specific Pancreatic Disease Outcomes

2025-06-11

Abstract excerpt

Mafa is a critical transcription factor in pancreatic beta-cell biology, orchestrating insulin expression in response to glucose elevations. As a member of the large MAF protein family, MAFA’s stability and activity are intricately regulated by GSK3-mediated phosphorylation. To decipher the functional roles of these phosphorylations, we engineered knock-in mice ( Mafa 4A /+ ) in which MAFA is rendered non-phosph...

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Literature Corpus work: f6ee287e-0dab-5fea-812c-6fb14a20937e
DOI: 10.1101/2025.06.11.659123

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