Article
Global changes in unproductive splicing and the NMD system efficiency in tumors
2025-12-12
Abstract excerpt
The Nonsense-Mediated Decay (NMD) pathway is a mRNA quality control mechanism, which not only degrades deleterious transcripts but also orchestrates a large number of post-transcriptional regulatory programs through unproductive splicing. Here, we developed a robust metric derived from the quantification of splicing in the RNA-seq data to measure NMD efficiency at a sample level. We demonstrate that NMD efficiency...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- f46382e5-d72b-5cdc-a71b-25dfb6542a6d
- DOI
- 10.64898/2025.12.10.692474