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Article

A spectrum of nonsense-mediated mRNA decay efficiency along the degree of mutational constraint.

Communications biology - 7 Nov 2024

Kim Young-Gon, Kang Hyunju, Lee Beomki, Jang Hyeok-Jae, Park Jong-Ho, Ha Changhee, Park Hogun, Kim Jong-Won

Abstract excerpt

Despite its importance for regulating gene expression, nonsense-mediated mRNA decay (NMD) remains poorly understood. Here, we extend the findings of a previous landmark study that proposed several factors associated with NMD efficiency using matched genome and transcriptome data from The Cancer Genome Atlas Program (TCGA) by incorporating additional data including Genotype-Tissue Expression (GTEx), gnomAD, and...

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Identifiers

PMID: 39511375
DOI: 10.1038/s42003-024-07136-y
PMCID: PMC11544006

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